Distribution: Fluticasone propionate has a large volume of distribution at steady-state (approximately 318L). Plasma protein binding is moderately high (91%). Pirinase is a nasal spray which helps provide relief for the symptoms of hay fever where they start. When you're outside allergens enter your body. Your body reacts by releasing 6 key substances. If you forget to take a dose, take it as soon as you remember. If it's nearly time for your next dose, skip the one you missed. Maximum benefit may require 3-4 days of continuous treatment in some people (see section 5.1, Pharmacodynamic Properties).

The full benefit of fluticasone propionate aqueous nasal spray may not be achieved until treatment has been administered for several days. It's important to use your spray regularly, even if you're feeling better. It will only help if it's used every day. If you miss a dose or take too much They can be used to treat a range of conditions, including hay fever, sinusitis, non-allergic rhinitis and nasal polyps. There is inadequate evidence of the safety of fluticasone propionate in human pregnancy. Administration of corticosteroids to pregnant animals can cause abnormalities of foetal development, including cleft palate and intra-uterine growth retardation. There may therefore be a very small risk of such effects in the human foetus. It should be noted however that the foetal changes in animals occur after relatively high systemic exposure; direct intranasal application ensures minimal systemic exposure. As with other drugs the use of this medicine during human pregnancy requires that the possible benefits of the drug be weighed against the possible hazards. As with other nasal sprays, dryness and irritation of the nose and throat, unpleasant taste and smell, headache and epistaxis have been reported.Pirinase Hayfever Relief for Adults 0.05% Nasal Spray is used to treat the symptoms of hay fever. Pirinase is non-drowsy treatment for all major hay fever symptoms. No other hay fever medicine is more effective without prescription.*

Before you use the nasal spray for the first time it needs to be primed by pumping it into the air a few times until a fine mist is produced. Hold the bottle upright and away from you while you're doing this. If the nasal spray hasn't been used for a few days you should reprime it in this way before using it again. Lots of people think that nasal sprays are only for nasal symptoms-but with Pirinase this is not the case. Pirinase not only treats nasal symptoms but also the itchy, watery eyes and that congested feeling that are common symptoms of hay fever. Under normal circumstances, low plasma concentrations of fluticasone propionate are achieved after intranasal dosing, due to extensive first pass metabolism and high systemic clearance mediated by cytochrome P450 3A4 in the gut and liver. Hence, clinically significant drug interactions mediated by fluticasone propionate are unlikely. If your symptoms last for more than seven days despite using Pirinase, get medical advice from your doctor.

Just one daily dose can provide unbeaten relief* from hay fever. Because Pirinase can last up to 24 hours, you don't need to carry it around, just spray once and you're ready for the day ahead. Pirinase Allergy 0.05% Nasal Spray treats the symptoms of hay fever and other airborne allergies. Used once a day, it can actually prevent symptoms from developing (with regular use). Pirinase Allergy 0.05% Nasal Spray is non- drowsy and available behind the counter in pharmacies. Pirinase allergy nasal spray can be bought over-the-counter from pharmacies to treat symptoms of nasal allergies such as hay fever, pet allergies or dust mite allergies in adults aged 18 years and over. Cataracts, raised pressure in the eye or glaucoma. Tell your doctor if you notice any changes in your vision while using Pirinase nasal spray.